Table 1 Comparison between clinical and hormonal profiles (whole cohort, n = 155) according to the etiology of azoospermia
|
OA n = 23 |
Unexplained NOA n = 69 |
Cryptorchidism NOA n = 25 |
Cytotoxic NOA n = 8 |
Genetic NOA n = 30 | |
|---|---|---|---|---|---|
|
Age at TESE (years) [median (IQR)] |
30 (28–35) |
34 (32-37.5) |
33 (31–37) |
28.5 (26.5–42.5) |
32.5 (29–37) |
| P-value | - | *0.01 | ns | ns | ns |
|
Mean testicular volume (mL) [median (IQR)] |
19.5 (15.1–22) |
9 (6.5–13.4) |
7 (6.4–9.7) |
5.6 (3.5;11) |
3.5 (2.3–7.4) |
| P-value | - | *<0.0001 | *<0.0001 | *<0.0001 |
*<0.0001 **<0.0001 ***0.01 |
|
FSH (IU /L) [median (IQR)] |
3.1 (1.8–3.8) |
17.2 (13.3–21.5) |
23.3 (15.4–30) |
17.3 (9.7–32.4) |
24.8 (17.8–31.5) |
| P-value | *<0.0001 | *<0.0001 | *0.0002 |
*<0.0001 **0.01 | |
|
LH (IU /L) [median (IQR)] |
2.9 (2-3.7) |
6.3 (4.9–8.3) |
5.3 (4.6–9.7) |
7.2 (6.5–9.7) |
9.8 (4.7–13.8) |
| P-value | *<0.0001 | *<0.0001 | *<0.0001 |
*<0.0001 **0.04 | |
|
Testosterone (ng/ml) [median (IQR)] |
5.5 (4.2–7.1) |
4.3 (3.5-5) |
3.9 (2.4–4.8) |
4.5 (2.4–6.8) |
3.2 (2-4.7) |
| P-value | *0.009 | *0.0007 | ns |
*<0.0001 **0.02 | |
|
AMH (pmol/l) [median (IQR)] |
44.8 (36-72.3) |
30.1 (15.2–58.5) |
21.8 (13.2–35.1) |
26.7 (10.4–41.6) |
7.3 (1.7–24.4) |
| P-value | *0.02 | *0.001 | *0.04 |
*<0.0001 **<0.0001 ***0.04 | |
| AMH/Testosterone [median (IQR)] |
1.1 (0.7–1.6) |
0.9 (0.5–1.9) |
0.7 (0.6–1.3) |
0.6 (0.4–1.3) |
0.2 (0.1–0.7) |
| P-value | ns | ns | ns |
*<0.0001 **<0.0001 ***0.005 | |
|
Inhibin B (pg/ml) [median (IQR)] |
166 (137–244) |
17 (10-32.5) |
11 (8-50.5) |
9.5 (9–38) |
9.5 (8-20.5) |
| P-value | *<0.0001 | *<0.0001 | *<0.0001 |
*<0.0001 **0.03 |